BacktoCricaddict Posted November 28, 2024 Author Posted November 28, 2024 (edited) Del double Edited November 28, 2024 by BacktoCricaddict
BacktoCricaddict Posted November 28, 2024 Author Posted November 28, 2024 (edited) @diga https://medicalxpress.com/news/2024-11-clinical-trial-reveals-yearly-hiv.html This is how science works. First we discovered that HIV causes AIDS. Then we launched projects to determine it's structure and unique components. Then we came up with models for how to attack those components. 1000s of molecules were tried in lab experiments. A few dozen promising ones made it into clinical trials. A few of those found to be effective and relatively safe. They were released to the market. The disease started to wane. Constant monitoring and R&D continued. More effective medicines were approved. Now we have one that - 2 injections per year - gives 96% reduction in viral loads. And then came RFK Jr. claiming that HIV doesn't cause AIDS. Anti establishment indeed. Edited November 28, 2024 by BacktoCricaddict Vicks57, Vijy and diga 1 2
diga Posted November 29, 2024 Posted November 29, 2024 15 hours ago, BacktoCricaddict said: @diga https://medicalxpress.com/news/2024-11-clinical-trial-reveals-yearly-hiv.html This is how science works. First we discovered that HIV causes AIDS. Then we launched projects to determine it's structure and unique components. Then we came up with models for how to attack those components. 1000s of molecules were tried in lab experiments. A few dozen promising ones made it into clinical trials. A few of those found to be effective and relatively safe. They were released to the market. The disease started to wane. Constant monitoring and R&D continued. More effective medicines were approved. Now we have one that - 2 injections per year - gives 96% reduction in viral loads. And then came RFK Jr. claiming that HIV doesn't cause AIDS. Anti establishment indeed. Right on cue.. world aids days is on Dec 1
Vijy Posted December 27, 2024 Posted December 27, 2024 On 11/28/2024 at 7:39 AM, BacktoCricaddict said: @diga https://medicalxpress.com/news/2024-11-clinical-trial-reveals-yearly-hiv.html This is how science works. First we discovered that HIV causes AIDS. Then we launched projects to determine it's structure and unique components. Then we came up with models for how to attack those components. 1000s of molecules were tried in lab experiments. A few dozen promising ones made it into clinical trials. A few of those found to be effective and relatively safe. They were released to the market. The disease started to wane. Constant monitoring and R&D continued. More effective medicines were approved. Now we have one that - 2 injections per year - gives 96% reduction in viral loads. And then came RFK Jr. claiming that HIV doesn't cause AIDS. Anti establishment indeed. according to RFK Jr, HIV is caused by alien rectal probe examinations
BacktoCricaddict Posted March 2 Author Posted March 2 https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group The latest data from the phase 1 trial are encouraging,” says Vinod Balachandran, MD, principal investigator of the trial and senior author of the new publication. “They suggest this investigational therapeutic mRNA vaccine can mobilize anti-tumor T cells that may recognize pancreatic cancers as foreign, potentially years after vaccination.” Prakat 1
BacktoCricaddict Posted May 16 Author Posted May 16 Science, beautiful science. https://www.usatoday.com/story/news/nation/2025/05/15/gene-editing-therapy-treatment-breakthrough/83598146007/ Quote Within minutes of KJ Muldoon’s birth, doctors knew there was something very wrong. Five weeks premature, his little arms went rigid when lifted and shook oddly on the way back down. An attentive doctor at the University of Pennsylvania, checking for a host of possible causes, noticed that KJ’s ammonia level was off the charts. He was rushed across the street to Children’s Hospital of Philadelphia, where doctors quickly offered a dire diagnosis. His body couldn’t clear ammonia, which is produced when the body turns protein from food into energy. Without being able to urinate it out, like healthy people do, the ammonia would build up and damage first his brain and then his whole body. By day two of KJ’s life, his parents Kyle and Nicole were getting the worst possible news: “I heard ‘death’ or ‘severely developmentally disabled.’ There wasn’t really a whole lot of getting around that,” Kyle remembered. Yet nine months later, KJ is smiling, sitting up unassisted and – on one recent day – happily eating avocado. “He’s defeated all odds and obstacles so far that were put in his way. He exceeds our expectations,” Nicole said in a May 12 call with reporters. All this is possible because KJ is the first-ever recipient of a gene therapy designed to treat only a single person. Every month for the past three, he’s received an infusion of billions of tiny balls of fat, containing instructions to edit genes in his liver cells. Fixing the genetic mistake in at least some of his liver cells enables his body to make an enzyme called CPS1, which is needed to break down protein. KJ’s ammonia level is now pretty close to normal. Long before KJ was born, a team of Penn doctors and researchers had been looking to test a never-before-tried treatment approach. Working through a company he helped found, Dr. Kiran Musunuru, a Penn cardiologist, had figured out how to gene-edit liver cells. KJ’s disease was serious enough that Ahrens-Nicklas wasn’t sure he’d make it to his first birthday, or what condition his brain would be in if he did. Even before telling KJ’s parents, Musunuru and Ahrens-Nicklas studied whether they might be able to fix his specific genetic mutation with an editing technology known as CRISPR. Some mutations remain beyond scientists' current ability to correct. Prakat and Tillu 2
BacktoCricaddict Posted May 17 Author Posted May 17 8 hours ago, Prakat said: Read about this in a different source. Beautiful indeed. The personalization, and the speed with which they went from diagnosis to treatment are mind-blowing. diga 1
BacktoCricaddict Posted May 17 Author Posted May 17 https://www.acsh.org/news/2025/05/06/cutting-edge-immunotherapy-offers-new-hope-glioblastoma-patients-49363 I lost a colleague to glioblastoma. She was 42 y.o with 2 little kids and held on for 2 yrs before succumbing. Fitness freak, absolutely brilliant mind and tireless advocate for the environment. If this was available 10 yrs ago... Newly discovered oncology drugs called “DNA-encoded tri-specific T-cell engagers,” or “DTriTEs,” engage the immune system more effectively than traditional therapies, particularly against evasive and deadly glioblastoma tumors. Prakat 1
crictime Posted June 12 Posted June 12 On 3/22/2024 at 1:41 AM, BacktoCricaddict said: Great point. But one must be careful to distinguish the types of diabetes. What you are talking about is Type 1 diabetes (T1D), which is an in-born, genetic, auto-immune disease in which insulin producing cells are attacked and killed by the patient's own immune cells. There is no cure so far - the patient has to get insulin injections lifelong. There are some cell-based therapies (like transplants) that have seen some success. But, some companies are looking at gene-editing technologies to cure this. But, in this case, it is very complex because you are trying to disarm immune cells that are trying to kill your own insulin-producing cells and that is not an easy task. It is not like single-mutation inborn errors like sickle-cell, beta-thalassemia or even cystic fibrosis where you can repair a single gene in specific cell types. What you and @gattaca alluded to as being managed by lifestyle changes is Type 2 diabetes (T2D). In most cases, this hits at advanced ages and can be managed (even reversed) by cutting refined grains, increasing fibre and protein intake, regular exercise to increase lean mass, and keeping weight down. I don't think this is a good target for gene editing. There are some other drugs available now (like Wegovy) that control appetite and thus help with weight-loss, but I feel they have more common side-effects than they are worth. If the fasting blood sugar is well in range, then still are there still any chances of Type 1. To be specific what is the range of type 1.
BacktoCricaddict Posted June 12 Author Posted June 12 5 hours ago, crictime said: If the fasting blood sugar is well in range, then still are there still any chances of Type 1. To be specific what is the range of type 1. The only way to definitively distinguish T1D from T2D is via an antibody test. T1D symptoms can be more severe, appear at a younger age, and be accompanied by low insulin levels compared to T2D. But sometimes T2D may present with severe symptoms and lower insulin levels. Back when I was growing up - they would just say that if you have diabetes at a young age - it is T1D, if you have it when you are older and it developed gradually, it is T2D.
crictime Posted June 12 Posted June 12 10 minutes ago, BacktoCricaddict said: The only way to definitively distinguish T1D from T2D is via an antibody test. T1D symptoms can be more severe, appear at a younger age, and be accompanied by low insulin levels compared to T2D. But sometimes T2D may present with severe symptoms and lower insulin levels. Back when I was growing up - they would just say that if you have diabetes at a young age - it is T1D, if you have it when you are older and it developed gradually, it is T2D. There is no separate range in diabetes report. The range is given as 70 to 99. What i wanted to ask is that does this 70 to 99 range includes Type 1 and Type 2 both.
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