Generic Ozempic will save millions of Indian lives.

[cowboysfan]

right now only the richest can affford in India it but soon the patents will go away and then obesity rates will go way down worldwide and especially in India.They wont improve their diet but atleast there will be a clinical way to beat obesity.

[kepler37b]

Ozempic, I heard, is not a single molecule like paraceptamol. It is biologic that is quite complex to produce.

 

Again, I am a noob in medicine. Resident bio tech gurus can comment more on this.

[cowboysfan]

3 hours ago, kepler37b said:

Ozempic, I heard, is not a single molecule like paraceptamol. It is biologic that is quite complex to produce.

 

Again, I am a noob in medicine. Resident bio tech gurus can comment more on this.

no ,it can already be produced for $5 in India,only patents holding the world back.

[kepler37b]

10 hours ago, cowboysfan said:

no ,it can already be produced for $5 in India,only patents holding the world back.

Thanks for correcting man. Pricing a non biologic like ozempic at that cost is pretty odd.

[zubinpepsi]

I thought ozempic is bad for the body.. my wife tried it and she stopped as it wasn’t doing her well.. the way ozempic works makes it hard to accept it as a medicine..

[cowboysfan]

8 hours ago, zubinpepsi said:

I thought ozempic is bad for the body.. my wife tried it and she stopped as it wasn’t doing her well.. the way ozempic works makes it hard to accept it as a medicine..

the only definite side effect i have noticed in some people who have taken it they look like they were in a concentration camp,they have lost so much wight so quickly that its hard to recognize them and they dont look healthy especially on their face.

[BacktoCricaddict]

Ozempic is technically a biologic because it is a "peptide" that is manufactured in a cell-based system (yeast cells) rather than by chemical synthesis. But, for being a biologic, it is on the smaller side (40 amino acids strung together), so it is regulated like a small non-biologic drug rather than a biologic (which is stupid, BTW, because cell-based systems have unique process issues). Just for perspective, its molecular weight is 4000, whereas paracetamol is just 151. 

 

At its core, it is an appetite suppressant. So, in the US, instead of it just being a T2D treatment, it has taken off as a cosmetic weight-loss treatment by people who can afford it, and telemedicine doctors who prescribe it willy-nilly. It's a mess.

 

The cost discussion is multifaceted. Yes, today it may cost only around $5 per dose to make, but the R&D to get it to this point has been going on for 26 years (it was first tested in animals in 1998). So, whoever invested in this R&D wants their ROI. Second, it is cheaper in nations where the govt negotiates prices based on their entire population. 

 

The only way for India to get into a leadership role in this area is to invest heavily in biotech R&D from the ground-level. Right now, there is intellectual and manufacturing capability, but still the dependence on licensing from abroad keep costs high. If India starts investing in basic rigorous, statistically-strong science today, it will reap the rewards in 40-50 years. 

 

 

Edited October 1, 2024 by BacktoCricaddict

[diga]

1 hour ago, BacktoCricaddict said:

Ozempic is technically a biologic because it is a "peptide" that is manufactured in a cell-based system (yeast cells) rather than by chemical synthesis. But, for being a biologic, it is on the smaller side (40 amino acids strung together), so it is regulated like a small non-biologic drug rather than a biologic (which is stupid, BTW, because cell-based systems have unique process issues). Just for perspective, its molecular weight is 4000, whereas paracetamol is just 151. 

 

Dhanyavada Guru... Any known side effects?

[kepler37b]

2 hours ago, BacktoCricaddict said:

Ozempic is technically a biologic because it is a "peptide" that is manufactured in a cell-based system (yeast cells) rather than by chemical synthesis. But, for being a biologic, it is on the smaller side (40 amino acids strung together), so it is regulated like a small non-biologic drug rather than a biologic (which is stupid, BTW, because cell-based systems have unique process issues). Just for perspective, its molecular weight is 4000, whereas paracetamol is just 151. 

 

At its core, it is an appetite suppressant. So, in the US, instead of it just being a T2D treatment, it has taken off as a cosmetic weight-loss treatment by people who can afford it, and telemedicine doctors who prescribe it willy-nilly. It's a mess.

 

The cost discussion is multifaceted. Yes, today it may cost only around $5 per dose to make, but the R&D to get it to this point has been going on for 26 years (it was first tested in animals in 1998). So, whoever invested in this R&D wants their ROI. Second, it is cheaper in nations where the govt negotiates prices based on their entire population. 

 

The only way for India to get into a leadership role in this area is to invest heavily in biotech R&D from the ground-level. Right now, there is intellectual and manufacturing capability, but still the dependence on licensing from abroad keep costs high. If India starts investing in basic rigorous, statistically-strong science today, it will reap the rewards in 40-50 years. 

 

 

Thanks man. This is a rigorous take.

[BacktoCricaddict]

2 hours ago, diga said:

 

Dhanyavada Guru... Any known side effects?

For sure. there are side-effects. The short-term ones are mostly digestive discomfort - nausea/vomiting, gas/bloating/abdominal pain. Although these just seem like inconveniences, they can actually be quite severe for some people. Anecdotally, I know folks who had to stop because the nausea/abdominal pain was really bad. Not everybody gets these side-effects, and many are quite happy taking it and controlling their diabetes.

 

In clinical trials, they are reports of long-term side-effects too, like pancreatitis. In some rare cases, thyroid cancer risk increases are also reported.

 

 

[cowboysfan]

The day has arrived-upto 50 Indian companies have already rolled out GLP-1 drug-Generic Ozempic and some are as cheap as 350 Rs a week.my only hope is people are exercising when they take this and also loading up on Protein.

[ravishingravi]

On 10/1/2024 at 7:27 PM, BacktoCricaddict said:

For sure. there are side-effects. The short-term ones are mostly digestive discomfort - nausea/vomiting, gas/bloating/abdominal pain. Although these just seem like inconveniences, they can actually be quite severe for some people. Anecdotally, I know folks who had to stop because the nausea/abdominal pain was really bad. Not everybody gets these side-effects, and many are quite happy taking it and controlling their diabetes.

 

In clinical trials, they are reports of long-term side-effects too, like pancreatitis. In some rare cases, thyroid cancer risk increases are also reported.

 

 

 

Ok. That's not very in inviting. I would rather swear it out. 

[FischerTal]

its better to take the GLP-1 and GIP combo aka Tirzepatide. Brand names are Mounjaro and Zepbound. Most common side effects are nausea/bloating and vomiting. It has led to cases of pancreatitis and medullary thyroid cancer in some people. Overall, it's safe(for now). We are still in uncharted territory. Nobody actually knows the long term effect of these drugs. The most concerning thing is the loss of lean mass that comes with it. People in India dont consume protein in adequate numbers like the West so the effect will be more visible. 

Edited March 21 by FischerTal

[kepler37b]

The issue is that this drug has to be taken forever. Else half the lost weight will come back. Again that is what gemini told me. The medical gurus here can chime in. 

[cowboysfan]

6 hours ago, kepler37b said:

The issue is that this drug has to be taken forever. Else half the lost weight will come back. Again that is what gemini told me. The medical gurus here can chime in. 

https://newsroom.clevelandclinic.org/2026/03/12/what-happens-when-patients-stop-taking-glp-1-drugs-new-cleveland-clinic-study-reveals-real-world-insights

 

this study basically says -

Those treated for obesity lost an average of 8.4% of body weight before discontinuation, and regained an average of 0.5% one year later.

 

its encouraging but if you go back eating Indian Carb heavy diet you will probably gain it all back.IMo those on these drugs who achieve targeted weight loss have to make a significant lifestyle changes forever to keep the weight off.

[G_B_]

On 9/29/2024 at 4:13 PM, cowboysfan said:

right now only the richest can affford in India it but soon the patents will go away and then obesity rates will go way down worldwide and especially in India.They wont improve their diet but atleast there will be a clinical way to beat obesity.

In pill form it will boost life expectancy by 5 to 6 years

 

[cowboysfan]

10 minutes ago, G_B_ said:

In pill form it will boost life expectancy by 5 to 6 years

 

not to mention the enormous cost of treating Diabetes in India,we have 100 million diabetics and another 100 million soon to be diabetic in India alone.If treated early these 80-90% of pre diabetic patients on GLP-1 will never progress to Type 2 Diabetes.

[randomGuy]

 

 

I have always been 20-21 bmi and ~15% body fat. Whenever I cross 21.5 bmi, I feel physically and mentally worse than when in my normal 20-21 zone.

 

So, I think people will feel a lot better if they weigh 8-10% lower as this drug promises. This will translate into their moods and on how they behave with others.

 

Hopefully this drug is safe enough!!

 

Also should strive for stress free life, proper sleep, walking, less oily, home food etc. for proper risk reduction of diabetes. That's more important.

 

 

Edited March 24 by randomGuy

[BacktoCricaddict]

On 3/21/2026 at 1:10 PM, ravishingravi said:

 

Ok. That's not very in inviting. I would rather swear it out. 

 

Compelling evidence that swearing can be a miracle weight-loss drug: 

 

Kohli before swearing

 

Kohli after swearing

 

 

[Lord]

Why can't science just make samosas healthy? or salads tastier?

 

@BacktoCricaddict Something to work on.