Khota Posted February 3, 2021 Posted February 3, 2021 Younger population will affect the mortality rate not the positivity rate. that has gone down which is encouraging.
BacktoCricaddict Posted February 3, 2021 Author Posted February 3, 2021 10 minutes ago, Khota said: Younger population will affect the mortality rate not the positivity rate. that has gone down which is encouraging. ...except that young asymptomatics are unlikely to get tested and indirectly bring down reported case numbers.
Khota Posted February 4, 2021 Posted February 4, 2021 6 hours ago, BacktoCricaddict said: ...except that young asymptomatics are unlikely to get tested and indirectly bring down reported case numbers. True. But are they testing any asymptomatic?
Vilander Posted February 4, 2021 Posted February 4, 2021 On 02/02/2021 at 10:48 AM, Clarke said: exposure to pathogens due to general lack of hygiene leading to better immunity. Damn. Too dirty for the virus to be effective basically hehe.. beetle 1
beetle Posted February 9, 2021 Posted February 9, 2021 Herd immunity in populated areas bcg vaccine taken by everyone Generally stronger immunity because of less sterile environment. A very huge ' younger' population . May be the conditions are more difficult for the virus and it is becoming weaker. Fairly good ( pretty harsh)control by the govt in the initial stages helped. Inspite of not having good infrastructure for hospital care....the disease control and management is fairly good. A lot of cases go unreported because of no mandatory testing for general population. The other factors given prevented the spread of these unreported cases. I was in Uttarakhand during covid. There was pretty harsh preventive measures taken during that time not just by govt but also by the people in the village. No one was allowed to enter village without the mandatory14 days quarantine and the panchayats were pretty active in providing quarantine shelter. I went back a few months back and people were still careful. Now I am back and barely anyone is wearing mask but the local population seems to be fine. Touch wood! nevada 1
rkt.india Posted February 9, 2021 Posted February 9, 2021 1 hour ago, beetle said: Herd immunity in populated areas bcg vaccine taken by everyone Generally stronger immunity because of less sterile environment. A very huge ' younger' population . May be the conditions are more difficult for the virus and it is becoming weaker. Fairly good ( pretty harsh)control by the govt in the initial stages helped. Inspite of not having good infrastructure for hospital care....the disease control and management is fairly good. A lot of cases go unreported because of no mandatory testing for general population. The other factors given prevented the spread of these unreported cases. I was in Uttarakhand during covid. There was pretty harsh preventive measures taken during that time not just by govt but also by the people in the village. No one was allowed to enter village without the mandatory14 days quarantine and the panchayats were pretty active in providing quarantine shelter. I went back a few months back and people were still careful. Now I am back and barely anyone is wearing mask but the local population seems to be fine. Touch wood! Your Village name?
Singh bling Posted February 9, 2021 Posted February 9, 2021 3 hours ago, beetle said: Herd immunity in populated areas bcg vaccine taken by everyone Generally stronger immunity because of less sterile environment. A very huge ' younger' population . May be the conditions are more difficult for the virus and it is becoming weaker. Fairly good ( pretty harsh)control by the govt in the initial stages helped. Inspite of not having good infrastructure for hospital care....the disease control and management is fairly good. A lot of cases go unreported because of no mandatory testing for general population. The other factors given prevented the spread of these unreported cases. I was in Uttarakhand during covid. There was pretty harsh preventive measures taken during that time not just by govt but also by the people in the village. No one was allowed to enter village without the mandatory14 days quarantine and the panchayats were pretty active in providing quarantine shelter. I went back a few months back and people were still careful. Now I am back and barely anyone is wearing mask but the local population seems to be fine. Touch wood! Herd immunity theory is still not accepted . Like cough and cold immunity last for 2-3 months. Vaccine effect is yet to come as first vaccine was given on 15 jan and you have to take two doses in 15 days and after the gap of 20-30 days so effect is yet to come. All I can say illnesses are still mystery for humans. Mariyam and beetle 2
beetle Posted February 9, 2021 Posted February 9, 2021 2 hours ago, rkt.india said: Your Village name? It is in pauri district. Bas
beetle Posted February 9, 2021 Posted February 9, 2021 25 minutes ago, Singh bling said: Herd immunity theory is still not accepted . Like cough and cold immunity last for 2-3 months. Vaccine effect is yet to come as first vaccine was given on 15 jan and you have to take two doses in 15 days and after the gap of 20-30 days so effect is yet to come. All I can say illnesses are still mystery for humans. True.....but we can only go by what info we have right now based on hard facts.
Clarke Posted February 10, 2021 Posted February 10, 2021 LATEST ENTRY: Protein deficiency, not age or weather, reason for spread of Covid in Europe, US The variant of the virus that spread rapidly across the world had acquired a mutation since it left Wuhan that allowed it to use another human protein called neutrophil elastase to also cleave the S1-S2 junction It was not the age profile or weather conditions, but the deficiency of a particular protein that led to the rapid spread of coronavirus disease (Covid-19) among Europeans and North Americans, according to a study by researchers from National Institute of Biomedical Genomics-Kalyani. The study was recently published in the journal Infections, Genetics and Evolution. The entry of the Sars-CoV-2 virus in the human body is a two-step procedure. First, the spike protein of the virus attaches to the ACE 2 (Angiotensin-Converting Enzyme 2) protein found on the surface of certain human cells in the lungs, intestine, and other tissues and organs. Second, another human protein TMPRSS2 (type II transmembrane serine protease) breaks the S1-S2 junction in the spike protein to allow the genetic material of the virus to enter the human cell. However, the variant of the virus that spread rapidly across the world had acquired a mutation since it left Wuhan that allowed it to use another human protein called neutrophil elastase to also cleave the S1-S2 junction. “Now the neutrophil elastase is used by the human body usually to kill the organism attacking the lungs. However, it also damages the lung tissue in the process. Hence, a protein called Alpha-anti-trypsin (AAT) is needed to balance its action. Our research shows that the deficiency of this AAT protein among the people in Europe and North America led to the rapid spread of the infection in these populations,” said Nidhan Biswas, the co-author of the article. The paper shows a co-relation between the level of AAT in populations and the spread of the infection, he said. “So far, we had seen that these regions were reporting higher number of cases but we did not know why. Some thought it was because of the elderly population or the cold weather. But, if you look at Japan it has a considerable old population but the disease was not as widespread. Conversely, the population of Brazil is younger and yet the disease was widespread. Now, we have shown that the reason for higher spread is the deficiency of AAT protein,” said Biswas. He said, “Even among the European population, the AAT deficiency is highest among those in Spain and Italy. And, Italy saw one of the biggest outbreaks initially.” The study has found a co-relation between the levels of AAT and the disease spread. However, the researchers have not found any link between the level of the protein and the severity of the disease. “This is the first time a co-relation has been established between this protein and the spread of Covid-19. However, this will have to be validated in appropriate cell lines and animal models. However, this gives us important information about the mechanism used by the virus to enter the human cells and the knowledge may be used to develop molecules in the future that can prevent the entry of the virus into the human body,” said Dr Soumitra Das, director, NIBMG. https://www.hindustantimes.com/india-news/protein-deficiency-not-age-or-weather-reason-for-spread-of-covid-in-europe-us-101612928342246-amp.html BacktoCricaddict and dial_100 2
dial_100 Posted February 10, 2021 Posted February 10, 2021 9 hours ago, Clarke said: LATEST ENTRY: Protein deficiency, not age or weather, reason for spread of Covid in Europe, US The variant of the virus that spread rapidly across the world had acquired a mutation since it left Wuhan that allowed it to use another human protein called neutrophil elastase to also cleave the S1-S2 junction It was not the age profile or weather conditions, but the deficiency of a particular protein that led to the rapid spread of coronavirus disease (Covid-19) among Europeans and North Americans, according to a study by researchers from National Institute of Biomedical Genomics-Kalyani. The study was recently published in the journal Infections, Genetics and Evolution. The entry of the Sars-CoV-2 virus in the human body is a two-step procedure. First, the spike protein of the virus attaches to the ACE 2 (Angiotensin-Converting Enzyme 2) protein found on the surface of certain human cells in the lungs, intestine, and other tissues and organs. Second, another human protein TMPRSS2 (type II transmembrane serine protease) breaks the S1-S2 junction in the spike protein to allow the genetic material of the virus to enter the human cell. However, the variant of the virus that spread rapidly across the world had acquired a mutation since it left Wuhan that allowed it to use another human protein called neutrophil elastase to also cleave the S1-S2 junction. “Now the neutrophil elastase is used by the human body usually to kill the organism attacking the lungs. However, it also damages the lung tissue in the process. Hence, a protein called Alpha-anti-trypsin (AAT) is needed to balance its action. Our research shows that the deficiency of this AAT protein among the people in Europe and North America led to the rapid spread of the infection in these populations,” said Nidhan Biswas, the co-author of the article. The paper shows a co-relation between the level of AAT in populations and the spread of the infection, he said. “So far, we had seen that these regions were reporting higher number of cases but we did not know why. Some thought it was because of the elderly population or the cold weather. But, if you look at Japan it has a considerable old population but the disease was not as widespread. Conversely, the population of Brazil is younger and yet the disease was widespread. Now, we have shown that the reason for higher spread is the deficiency of AAT protein,” said Biswas. He said, “Even among the European population, the AAT deficiency is highest among those in Spain and Italy. And, Italy saw one of the biggest outbreaks initially.” The study has found a co-relation between the levels of AAT and the disease spread. However, the researchers have not found any link between the level of the protein and the severity of the disease. “This is the first time a co-relation has been established between this protein and the spread of Covid-19. However, this will have to be validated in appropriate cell lines and animal models. However, this gives us important information about the mechanism used by the virus to enter the human cells and the knowledge may be used to develop molecules in the future that can prevent the entry of the virus into the human body,” said Dr Soumitra Das, director, NIBMG. https://www.hindustantimes.com/india-news/protein-deficiency-not-age-or-weather-reason-for-spread-of-covid-in-europe-us-101612928342246-amp.html This is interesting. I read this 2-3 days ago. Its plausible.
MechEng Posted March 1, 2021 Posted March 1, 2021 In a country where everyone is atmanirbhar, the COVID virus will naturally fail to find a host because it has to be self reliant in Modiji's India. Clarke and Under_Score 2
Yoda-esque Posted March 1, 2021 Posted March 1, 2021 Modi gets his covaxin Now what will toti chor say?
Clarke Posted March 1, 2021 Posted March 1, 2021 (edited) 4 hours ago, MechEng said: In a country where everyone is atmanirbhar, the COVID virus will naturally fail to find a host because it has to be self reliant in Modiji's India. Will the virus mutate into more dangerous forms if it doesn't get MSH - minimum support hosts ? After all we didn't consult them with talks before coming up with vaccination. Edited March 1, 2021 by Clarke Mariyam, dial_100, MechEng and 1 other 1 3
G_B_ Posted March 1, 2021 Posted March 1, 2021 On 2/2/2021 at 3:30 PM, BacktoCricaddict said: https://www.npr.org/sections/goatsandsoda/2021/02/01/962821038/the-mystery-of-indias-plummeting-covid-19-cases This topic is now at the forefront of public health discussions. Scientists have brought up a number of hypotheses: strict mask mandates, younger demographic, more exposure to other pathogens and warm weather seem to be the most discussed reasons. I am surprised that there is not enough discussion given to two other possibilities: (1) BCG vaccine: Early on, there were some strong correlations that countries with widespread BCG vaccinations (anti-TB) were doing better with CoViD. The jury is still out on this hypothesis and it has lost the early steam. (2) Local medications: Many people have been consuming kadhaa (kashaayaa/m) and herbals like Coronil and shvasari. While I don't think the biological basis for these preparations is strong and that they have been adequately tested, I am not ready to summarily dismiss them. I wish that there was more attention paid to their efficacy - from both sides. How many people took these preparations, how often, how did Covid numbers correlate to them etc. etc.? These are excellent opportuntieis to develop evidence-based cures that India can proudly hold up as their indigenous medicine and bring it to the world. But what we have are, on the one hand, practitioners rejecting the call to do rigorous studies and, on the other hand, supporters of modern medicine completely rejecting these treatments without giving them a chance at all. When will the two meet and take advantage of the great opportunities? Add another point. Obesity. Will be interesting in India to see how states have performed. I noticed fattest regions like Delhi and Mumbai have done the worst.
G_B_ Posted March 1, 2021 Posted March 1, 2021 In general my message to posters here is. Covid-19 is a prime example of the merits of being fit. You dont need to have a supermodel body with 6 packs or 24 inch waist. Just maintain a BMI between 18 to 23. If your a guy aim for a waist 34 inches or less. I notice a lot of fatties in Mumbai and Delhi. Each year the CBSE toppers are bordering on obese. If your an indian living in the west watch out for vitamin D deficiency. It is an issue that plagues the South Asian community in the UK. Incorporate plenty of Ginger and spices in your diet to give you a long term shield. We make it a point to add a bit of turmeric in our cooking to the point where it does not impact the taste of the food (unless its part of the dish) The truth is the media likes to rate the performance of countries. But it is a futile exercise. A old and fat country will do worse in covid than a young healthy country. Why blame the current admin for a demographic differences? Mariyam, coffee_rules, dial_100 and 1 other 3 1
G_B_ Posted March 1, 2021 Posted March 1, 2021 As to have the cases are tumbling , you need to do a proper model like a Cox proportional hazards model. Based on the same you would know which factors impact the chance of the hazard (death). You can add variables on weather like humidity, sunshine hours temperature. age gender (women have stronger immune systems) smokers , general proportion of population with comorbidities like obesity (interaction term with age), population density, size of household, when covid hit the country in relation to general infections (Indian infections spike in the monsoon season, had covid hit then it might have been worse). you can also have a globalisation index per country in terms of international air passenger arrivals per capita as transport hubs are hit or not, how porous are a countries borders (island nations will in general be at an advantage). A neighbourhood index to see if your general neighbourhood of countries is hit etc etc. Once you identify key factors , you need to rank them in terms of salience. Then you need need to identify which of these factors apply to India. For the record, its not just India. South Asian countries are in the same boat. Places like SL benefit from being an island and shut up shop easily. BD and Pakistan have much younger populations than india which has kept death counts low. BacktoCricaddict 1
coffee_rules Posted March 1, 2021 Posted March 1, 2021 (edited) This is a wrong step. If more gets vaccinated, esp the elderly, less likely it will transmit across the public. With such a stance, you cause more harm than good. Some doctor should advise him. Edited March 1, 2021 by coffee_rules Jimmy Cliff 1
Austin 3:!6 Posted March 1, 2021 Posted March 1, 2021 (edited) 9 hours ago, coffee_rules said: Modi gets his covaxin Great leader and always lead by example. Indians will realize his worth once he leaves. Edited March 1, 2021 by Austin 3:!6 coffee_rules, kepler37b and G_B_ 2 1
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